An example of a statistically misleading MMR vaccine argument

I woke up this morning to a twitter comment about the “CDC Whistleblower Saga” from last year from one of my favorite twitter followers.  This obviously led to a conversion explaining to me that: vaccines aren’t effective, the idea of herd immunity has been debunked, they are making kids sick, and they cause autism (Vaccines Don’t Cause Autism). I should note that none of these claims have any scientific backing to them.  Other twitterers also told me that vaccines aren’t 100% effective (true; MMR is about 93% and 97% effective for 1 and 2 doses, respectively) and vaccines have side effects (also true, though side effects are rare).   But also, not a logical argument against vaccination.  I think we often forget (or in my case, never saw (thank you vaccines!)) how bad the measles really is (the measles are horrible).

And I know deep down, that no matter what I say, I’m not going to change someone’s mind on twitter.  So why do I engage in “discussions” with people like this.  I guess first, I can’t help myself.  If someone engages me first, and they are wrong, I’m going to tell them that they are wrong.  Though I’m not sure this is the best way to effectively deal with the anti-vaccine crowd (Here is how Jamelle Bouie of Slate suggests dealing with them), but I can’t help myself.  I do try not to insult or attack people, but rather their arguments.  But I find this difficult to do sometimes when I believe that these people are actively causing harm by trying to spread their anti-vaccines beliefs.  (So if I insulted you today, I apologize to you.  I should be better than that.  But I still think your ideas are pseudo-scientific cray-ball wackadoo stuff).

But, secondly, I am absolutely fascinated that people think this way.  It’s so foreign to how I think about the world.  I know people who are espousing these beliefs actually believe them in spite of the mountains of evidence against their claims.  To this end, The Atlantic wrote a really interesting article last fall about the psychology of anti-vaxers.  It’s a fascinating read.   And a bit sad with quotes like this: 

Dr. Douglas Hulstedt, a pediatrician in Monetery, California, shares Smoot’s preference for personal stories over scientific evidence. Hulstedt accepts patients who are not vaccinated. He goes even further, and recommends refusing vaccinations if a patient has a family history of autism, lupus, Crohn’s disease, or Type 1 diabetes.

“Why do I need a medical study?” he says. “If 80 percent of the parents of children with regressive autism in my practice say their child reacted after the MMR [measles, mumps, and rubella] shot, why do I need a medical study?” Hulstedt says that studies showing no link between the MMR vaccine and autism or showing that vaccines are safe and effective might have “fraud in the reportage.”

This is a medical doctor posing the question: “Why do I need a medical study?”.  That is absolutely appalling and evidence why I believe medical doctors need more statistical training before, during, and after medical school.  Statistics is a complicated subject.  Statistics is hard.  I find it is constantly difficult, and I’m supposed to be the “expert”.  But it’s just a difficult subject to tackle.  Statistics is hard.   But we need it as part of the scientific method to objectively answer medically important questions.  Like do vaccine work (Yes).

But it’s so easy to make mistakes.  As an illustration, let’s consider the plot below which shows measles deaths per 100,000 people over time.  This was sent to me by my favorite twitter follower with the (sarcastic) text:

As you can see #MeaselsVaccine [sic] is instrumental in eradicating #Measels [sic]

Screen Shot 2015-07-22 at 3.51.50 PM

They are arguing (I believe) that the death rate from measles was dropping for decades prior to the introduction of the measles vaccine, and the measles vaccine did little to lower the death rate of  measles.  So it follows that the measles vaccine isn’t as effective as science makes it out to be, therefore CONSPIRACY! #tinfoilhat #jadehelm

In all seriousness though, if you have no statistical knowledge, this might seem like a convincing argument.  And I’m sure there are a lot of smart people (and not so smart people) who could be convinced by this plot.  The problem with this is that this “analysis” is inherently trying to isolate the effect of vaccines on death rates without controlling for any other factors that are related to the death rate.  Medicine advanced quite a bit from 1840 to 1940 and the probability of dying from measles dropped considerably.  Even with no vaccines.  But that’s all this plot is demonstrating.  And it’s offering almost no evidence as to the effectiveness of the vaccine and is a case study in confounding.

I’d also argue the that graph is potentially misleading the viewer with scales.  By the time the vaccine is introduced in that graph, the line is so close to 0/100,000 that it’s hard to see the relative effect of the vaccine.  The death rate could have dropped 10% or 90% (It does drop some amount) and the viewer wouldn’t be able to tell .  The graph would be much stronger if it was zoomed in on the years 1948 to 1978.  But that doesn’t seem to be the narrative that is trying to be passed on with that graphic.

Screen Shot 2015-07-22 at 3.54.16 PM

To really get a handle on the effectiveness of vaccines, we should be looking at cases of measles rather than the measles death rate.  The graph below shows cases of measles in the US from 1954 through 2008.  The first vaccine was introduced in 1963 and a second version was released in 1968.  Notice the large and immediate drop from 1963 to 1969.  It’s possible that there could be some huge confounding effect that explains this drop, but I think it would be difficult to present a reasonable confounding effect here that would dwarf the effect of the introduction of vaccines.  The decline in measles cases was immediate and rapid.  So are vaccines effective in reducing disease?  Yes. Yes. Yes. Yes. Yes. and finally Yes.

Finally, I’ll close with this advice from the World Health Organization (WHO) an trying to persuade the anti-vaxxers:

How one addresses the anti-vaccine movement has been a problem since the time of Jenner. The best way in the long term is to refute wrong allegations at the earliest opportunity by providing scientifically valid data. This is easier said than done, because the adversary in this game plays according to rules that are not generally those of science.  This issue will not be further addressed in this paper, which aims to show how vaccines are valuable to both individuals and societies, to present validated facts, and to help redress adverse perceptions. Without doubt, vaccines are among the most efficient tools for promoting individual and public health and deserve better press.8

You can (and should) read the whole paper here.



Posted on July 22, 2015, in Uncategorized. Bookmark the permalink. 3 Comments.

  1. Great post, SITW. Note also, that eradication of measles has been shown fairly convincingly to decrease attack rates from other diseases. Measles makes you vulnerable to other severe diseases!

  2. Apparently, merely licensing the vaccine causes the drop since the measles vaccine was not wifely used until 1967. The cases of morbidity were effectively zero before the vaccine was widely used, even according to your second graph. So, as it you state, there were obviously other factors involved.

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